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EffRx Announces the Appointment of Göran Linder to of the Board of Directors

Freienbach, July 21, 2021 — EffRx Pharmaceuticals SA, a commercial-stage pharmaceutical company focused on the late-stage development and commercialization of prescription medications for niche and orphan indications, today announced the appointment of Göran Linder to its Board of Directors.

“As the representative of EffRx’s major shareholder, I actively promoted the turn-around that the company and its highly professional staff so successfully completed a few years back. EffRx is now a solid and profitable company with lots of inherent and exciting potential. By joining the Board, it is my ambition to facilitate further development of the business and to proactively materialize a more extended and ambitious company roadmap,” commented Göran Linder, Board Member.

Göran Linder joins existing Board Members, Dr. Jonas Ekblom, Chairman and Dr. Alcide Barberis. Mr. Linder has over 30 years of diversified sales, business development and management experience. He is a proven, dedicated leader and entrepreneur, with a successful track record to grow start-ups and to generate shareholder value, including in numerous Life Science exits and IPO’s.

Mr. Linder is currently CEO and Member of the Board at Midroc Invest AB, Midroc New Technology AB and Midroc Finans AB. The Midroc Group of Swedish venture capital companies targets groundbreaking technologies entailing new and more sustainable ways to produce energy, grow food, purify water, produce goods and cure diseases. Additionally, Mr. Linder serves as Chairman and Board Member at several IT, Life Science and Cleantech companies.

About EffRx Pharmaceuticals

EffRx Pharmaceuticals is a commercial-stage pharmaceutical company focused on the late-stage development and commercialization of prescription medications for niche and orphan indications. The business model is centered around providing superior clinical and commercial value propositions for physicians, payers and patients.

EffRx pro-actively seeks in-licensing opportunities for Europe in niche therapeutic areas, with a primary interest for rare diseases, where EffRx has received an orphan drug designation (ODD) from the FDA for a pipeline asset.

EffRx’s go-to-market competence is proven by the development, launch and lucrative expansion of Binosto® in a highly competitive European market.  Our lead commercialized product, Binosto® for the treatment of osteoporosis, is marketed in the US as well as selected European and Asian countries.

A Prospective Study in More Than 1,000 Osteoporosis Patients Concluded That Binosto® (Buffered Soluble Alendronate) May Increase Patient Satisfaction, Long-Term Adherence and Therefore Efficacy

FREIENBACH, Switzerland–(BUSINESS WIRE)–

Corporate IR Press Release

In a newly published international multicenter study1 in over 1,000 osteoporosis patients treated with Binosto® and followed for 12 ± 3 months,

  • Binosto was well tolerated
  • Treatment persistence was high
  • Mean overall compliance was high too
  • Patient satisfaction remained at approximately 90%

EffRx Pharmaceuticals SA, a commercial-stage pharmaceutical company that commercializes niche and orphan medicines in Switzerland and Europe, announces the full paper publication of the GastroPASS Study Results of Binosto® (buffered soluble alendronate) in JBMR® Plus, a premier peer-reviewed medical journal. Prof. Salvatore Minisola will present the study results as an oral communication (OC 19) at the WCO-IOF-ESCEO2 virtual congress on August 28, 2021 at 11:40 am.

GastroPASS was a prospective, observational, multicenter, multinational, single-arm, post-authorization safety study. The study enrolled 1,084 postmenopausal women with osteoporosis, newly prescribed Binosto® and naïve to bisphosphonate therapy. At baseline, 31% of enrolled patients reported a medical history of gastrointestinal (GI) tract conditions that did not exclude study participation. Patients were followed for 12 ± 3 months. The primary objective was to evaluate the incidence of upper GI adverse events and medication errors during treatment. Secondary aims were to evaluate persistence, discontinuation and reasons for discontinuation.

The cumulative incidence of all upper GI AEs related to Binosto® observed during the duration of the study was low at 9.6%. The study authors stated that “the incidence of upper GI AEs in this “real-world” study were found to be lower than that observed in alendronate-treated groups from randomized controlled trials with a duration of 12 months.” Also, the incidence rate of individual gastric AEs related to Binosto was low (ranging from 0 to 2.1 per 1,000 patients/month) and decreased over the three follow-up periods of the study. No events for gastric ulcer, gastric perforation, gastric hemorrhage, and gastric stenosis were observed.

Treatment persistence reported in this study was high at 79.7% at 12 ± 3 months. These results are well in line with the recently published findings by Giusti et al.3 Mean overall compliance was high, too, at 92.8 using the Morisky-Green questionnaire and 94.8 based on the number of tablets missed.

Patient satisfaction and preference were also high, at approximately 90%, both in terms of how easy it was to take Binosto® and how much easier it was to take Binosto compared with other medications.

“Prof Minisola et al have conducted an interesting study. Results are interesting and needed, considering that alendronate is still a very important medication. (…) Oral bisphosphonates are considered the first line treatment in patients after fragility fractures. The present data are encouraging in terms of low prevalence of GI side effects. (…) To prescribe medications with low rate of side effects is important also during the pandemic, given the restrictions and limited access to osteoporosis clinics.”, commented one of the independent reviewers of JBMR Plus.

Overall, post-menopausal women with osteoporosis treated with Binosto® (buffered soluble alendronate) in a real-world setting experienced few upper GI AEs. In addition, they had a low discontinuation and high compliance compared to other formulations, suggesting that buffered soluble alendronate may increase patient satisfaction and therefore long-term adherence and efficacy.

“Based on my experience as the PI and first author of the pivotal trial on alendronate, a first-line treatment in osteoporosis, I believe that this study was needed and the results are relevant to provide good evidence for this alternative formulation of alendronate. The low incidence of upper GI AEs, the low discontinuation rate and the high compliance observed in the study reinforce previous clinical data regarding Binosto. These results offer confidence that Binosto could lead to increased patient satisfaction and therefore better long-term adherence and efficacy than pill forms.” commented Prof. Dennis M Black, study co-author.

1 The full paper publication can be found at: JBMR® Plus

2 World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases

3 Giusti A et al. A novel effervescent formulation of oral weekly alendronate (70 mg) improves persistence compared to alendronate tablets in post-menopausal women with osteoporosis. Aging Clin Exp Res 2021; https://doi.org/10.1007/s40520-020-01777-9.

About JBMR® Plus

JBMR® Plus is the premier open access journal of the American Society for Bone and Mineral Research (ASBMR). A companion to internationally recognized title Journal of Bone and Mineral Research, JBMR® Plus aims to improve global musculoskeletal health by publishing innovative research covering endocrinology, geriatrics, orthopedics and rheumatology.

About EffRx Pharmaceuticals

EffRx Pharmaceuticals is a commercial-stage pharmaceutical company focused on the late stage development and commercialization of prescription medications for niche and orphan indications. The business model is centered around providing superior clinical and commercial value propositions for physicians, payers and patients.

EffRx’s go-to-market competence is proven by the development, launch and successful expansion of Binosto® in highly competitive markets.

EffRx pro-actively seeks in-licensing opportunities for Europe in niche therapeutic areas, with a primary interest for rare diseases, where EffRx has received an orphan drug designation (ODD) from the FDA for a pipeline asset.

About Binosto®

Binosto® (Buffered Soluble Alendronate) is a first-line treatment of postmenopausal osteoporosis patients that is associated with preferable pharmacologic properties translating into clinical benefit for patients. Alendronate as recommended by guidelines is a first line treatment for postmenopausal women with osteoporosis. Alendronate 70 mg tablet once weekly is the most commonly used bisphosphonate but adherence is problematic, with >50% discontinuing treatment within the first year. To address this, Binosto®, a novel buffered soluble alendronate 70 mg effervescent tablet formulation was specifically developed to improve GI tolerability and adherence to treatment.

EffRx Seeks New Business Collaborations at the BIO International Convention Digital 2021

At the BIO International Convention Digital, taking place June 10-11 & 14-18, 2021, EffRx pro-actively seeks in-licensing opportunities for Europe in niche therapeutic areas, with a primary interest for rare diseases. Registered companies can still meet with EffRx in virtual BIO One-On-One Partnering meetings. Please contact us via the partnering platform or at info@effrx.com.

BIO is the world’s largest advocacy association representing member companies, state biotechnology groups, academic and research institutions, and related organizations across the United States and in 30+ countries.

Dr. Nathalie Véron Appointed Director Technical Operations & Qualified Person at EffRx Pharmaceuticals

FREIENBACH, Switzerland – EffRx Pharmaceuticals SA is pleased to announce the appointment of Dr. Nathalie Véron as Director Technical Operations & Qualified Person. She is responsible for overseeing all technical operations activities at EffRx, such as manufacturing relations, supply chain and quality management.

Prior to joining EffRx, Dr. Véron has held various local and global, cross-functional leadership positions in Manufacturing Science and Technology at F. Hoffmann-La Roche, Technical Operations. In addition, she significantly contributed to Digital Supply Chain and Quality Transformation projects in the pharmaceutical industry.

Dr. Véron is a pharmacist by education, who graduated from the University of Freiburg, Germany. She holds a PhD in Biology from the Free University Berlin, Germany and has over 10 years of experience as a Biomedical Scientist.

“We are excited to have such an experienced and dynamic person joining our diverse team,” said Mr. Lorenzo Bosisio, CEO of EffRx Pharmaceuticals. “Nathalie’s capabilities will play an important role in the direct commercialization of niche and orphan medicines by EffRx as well as to further advance our operational standards.”

Dr. Véron commented, “I am excited to contribute to the growth and value creation of this dynamic, innovative company, given the smart and passionate people in the Company and its expanding portfolio of products for new and orphan therapeutic areas. I believe that the company’s approach to deliver innovative, high quality products allows us to make a difference for the patients.”

About EffRx Pharmaceuticals

EffRx Pharmaceuticals is a commercial-stage pharmaceutical company focused on the late stage development and commercialization of prescription medications for niche and orphan indications. The business model is centered around providing superior clinical and commercial value propositions for physicians, payers and patients.

EffRx pro-actively seeks in-licensing opportunities for Europe in niche therapeutic areas, with a primary interest for rare diseases, where EffRx has received an orphan drug designation (ODD) from the FDA for a pipeline asset.

EffRx’s go-to-market competence is proven by the development, launch and lucrative expansion of Binosto® in a highly competitive European market.  Our lead commercialized product, Binosto® for the treatment of osteoporosis, is marketed in the US as well as selected European and Asian countries.

EffRx Pharmaceuticals Announces the Release of Binosto® Data in Two Publications

FREIENBACH, Switzerland – EffRx Pharmaceuticals SA, a commercial-stage company that commercializes niche and orphan medicines in Switzerland and Europe, today announced the publication of new scientific data on its Binosto® (buffered soluble alendronate). The data appeared in two major medical journals.1,2

The findings from the study “A novel effervescent formulation of oral weekly alendronate (70 mg) improves persistence compared to alendronate tablets in post‑menopausal women with osteoporosis” demonstrate that Binosto® can provide greater persistence and improved tolerability compared to alendronate tablets, allowing it to be a viable alternative option in the management of osteoporosis.

The article “Cost-effectiveness of buffered soluble alendronate 70 mg effervescent tablet for the treatment of postmenopausal women with osteoporosis in Italy” provides an economic analysis which indicates that Binosto® may represent a cost-effective strategy compared with relevant alternative treatments for the treatment of postmenopausal women with osteoporosis in Italy aged 60 years and over.

Both publications can be found at: https://doi.org/10.1007/s40520-020-01777-9 and https://doi.org/10.1007/s00198-020-05802-5

  1. Giusti, A., Bianchi, G., Barone, A. et al. A novel effervescent formulation of oral weekly alendronate (70 mg) improves persistence compared to alendronate tablets in post-menopausal women with osteoporosis. Aging Clin Exp Res (2021). https://doi.org/10.1007/s40520-020-01777-9
  2. Hiligsmann, M., Maggi, S., Veronese, N. et al. Cost-effectiveness of buffered soluble alendronate 70 mg effervescent tablet for the treatment of postmenopausal women with osteoporosis in Italy. Osteoporos Int (2021). https://doi.org/10.1007/s00198-020-05802-5

 

About EffRx Pharmaceuticals

EffRx Pharmaceuticals is a commercial-stage pharmaceutical company focused on the late stage development and commercialization of prescription medications for niche and orphan indications. The business model is centered around providing superior clinical and commercial value propositions for physicians, payers and patients.

EffRx pro-actively seeks in-licensing opportunities for Europe in niche therapeutic areas, with a primary interest for rare diseases, where EffRx has received an orphan drug designation (ODD) from the FDA for a pipeline asset.

EffRx’s go-to-market competence is proven by the development, launch and lucrative expansion of Binosto® in a highly competitive European market. Our lead commercialized product, Binosto® for the treatment of osteoporosis, is marketed in the US as well as selected European and Asian countries.

Disclaimer: Information for investors. Please always refer to the official Prescribing Information of Binosto® containing the approved indications, contraindications, safety information and warnings in your country.

 

 

EffRx Pharmaceuticals Signs Exclusive License Agreement with Dipharma SA and Launches Miglustat Dipharma in Switzerland

FREIENBACH, Switzerland – EffRx Pharmaceuticals SA, a commercial-stage company that commercializes niche and orphan medicines in Switzerland and Europe, today announced it has recently entered into an exclusive license agreement with Dipharma SA, a Swiss specialty pharmaceutical company, developing high quality, improved medicines for rare diseases. Under the terms of the agreement, EffRx has received exclusive rights to commercialize Miglustat Dipharma in Switzerland.

Miglustat Dipharma is a generic equivalent to Actelion’s (Johnson & Johnson’s) Zavesca®1. It is indicated for the oral treatment of adult patients with mild to moderate type 1 Gaucher disease for whom enzyme replacement therapy is unsuitable, as well as for the treatment of progressive neurological manifestations in adult and pediatric patients with Niemann-Pick type C disease.

Gaucher disease and Niemann-Pick disease belong to a larger group of more than 50 disorders known as lysosomal storage disorders. They are inherited metabolic diseases that are characterized by an abnormal build-up of various toxic materials in the body’s cells as a result of enzyme deficiencies.

Patients with mild to moderate type 1 Gaucher disease lack an enzyme called glucocerebrosidase, which results in a glycosphingolipid called glucosylceramide building up in different parts of the body, such as the spleen, liver and bones. Miglustat Dipharma is used in patients who cannot receive the standard treatment of enzyme replacement therapy. Niemann-Pick type C is a potentially fatal disease in which glycosphingolipids build up within cells in the brain and elsewhere in the body. Miglustat Dipharma is used to treat the neurological symptoms of the disease.

The addition of Miglustat Dipharma marks another milestone for EffRx Pharmaceuticals’ growing portfolio of niche and orphan medicines in Switzerland. After having secured the rights for innovative therapies to treat conditions like cystic fibrosis and pediatric adrenal insufficiency, EffRx is thrilled to be able to launch a product which has an established place in the treatment of two major lysosomal storage disorders.

Miglustat Dipharma is reimbursed in Switzerland as of 1 November 2020.2 It provides a therapeutic alternative for patients and important cost savings for the Swiss healthcare system.

About EffRx Pharmaceuticals

EffRx Pharmaceuticals is a commercial-stage pharmaceutical company focused on the late stage development and commercialization of prescription medications for niche and orphan indications. The business model is centered around providing superior clinical and commercial value propositions for physicians, payers and patients.

EffRx pro-actively seeks in-licensing opportunities for Europe in niche therapeutic areas, with a primary interest for rare diseases, where EffRx has received an orphan drug designation (ODD) from the FDA for a pipeline asset.

EffRx’s go-to-market competence is proven by the development, launch and lucrative expansion of Binosto® in a highly competitive European market. Our lead commercialized product, Binosto® for the treatment of osteoporosis, is marketed in the US as well as selected European and Asian countries.

About Dipharma SA

Dipharma S.A. is a Swiss specialty pharmaceutical company, developing high quality, improved, medicines for rare diseases. Dipharma S.A. is part of a third-generation group of family-owned companies that have grown to a global presence.

With a portfolio of generic orphan products for the treatment of Phenylketonuria, Gaucher Disease, Hereditary Tyrosinemia Type 1, Urea Cycle Disorders and others, Dipharma S.A. provides improved solutions for patients affected by inborn metabolic diseases at an affordable cost and with a global reach.

For more information, please visit www.dipharma.ch

Media contact: Ms. Pamela Saredi, psaredi@effrx.com

1 Zavesca® is a registered trademark of Actelion Pharmaceuticals Ltd.
2 Reimbursed for the treatment of adult patients with mild to moderate type 1 Gaucher disease for whom enzyme replacement therapy is not possible.

EffRx Pharmaceuticals Signs Exclusive License Agreement with Diurnal for the Registration and Commercialization of Alkindi® and Submits Market Authorization Application in Switzerland

FREIENBACH, Switzerland (BUSINESS WIRE)-– EffRx Pharmaceuticals SA, a commercial-stage company that commercializes niche and orphan medicines in Switzerland and Europe, today announced it has recently entered into an exclusive license agreement with Diurnal Group plc, a specialty pharmaceutical company targeting patient needs in chronic endocrine diseases, for the registration and commercialization of Alkindi® for pediatric adrenocortical insufficiency (AI) in Switzerland. Under the terms of the agreement EffRx has received the exclusive rights to register and commercialize Alkindi® in Switzerland.

Alkindi® is the first preparation of hydrocortisone specifically designed for use in children suffering from paediatric adrenocortical insufficiency (AI). Alkindi® is a patented, oral, immediate-release paediatric formulation of hydrocortisone granules in capsules for opening that allows for accurate age-appropriate dosing in children. This therapeutic approach has the potential to help young patients less than eighteen years of age suffering from pediatric AI and the related condition congenital adrenal hyperplasia (CAH).

Alkindi® is already approved and marketed in the European Union and is the first preparation of hydrocortisone specifically designed for use in children suffering from AI. On September 29th, 2020 the US Food and Drug Administration (FDA) has also approved Alkindi® for AI.

EffRx has recently submitted to Swissmedic (Switzerland) a Market Authorization Application for the registration of Alkindi®. Pending successful regulatory registration, this new treatment approach is expected to be available on the Swiss market by 2022. In Switzerland there are approximately 200 patients suffering from pediatric AI.

We are extremely pleased to announce this partnership with Diurnal which demonstrates EffRx capability to expand its portfolio with promising niche and orphan medicines”, commented Lorenzo Bosisio, CEO of EffRx Pharmaceuticals. “We look forward to bringing this novel therapeutic approach to Switzerland. We are confident that Alkindi® provides a tangible advancement for young patients suffering from AI and their carers.

Martin Whitaker, CEO of Diurnal, commented: “This partnership with EffRx further validates the quality of our products and broadens the future availability of Alkindi®. EffRx is well-placed to register and market our product Alkindi® in Switzerland. We have made strong progress with the sales of Alkindi® across Europe since its approval and subsequent launch in 2018, and we are confident this agreement will enable further growth.”

Pediatric AI, including the genetic condition CAH is a condition characterised by deficiency in cortisol, an essential hormone in regulating metabolism and the response to stress. The primary symptoms of AI are chronic fatigue and patients are at risk of adrenal crisis and death if they do not have adequate cortisol replacement. AI is either primary or secondary, with primary AI resulting from diseases intrinsic to the adrenal gland and secondary AI resulting from pituitary diseases where there is a failure of stimulation of the adrenal by the pituitary of the signalling hormone ACTH (adrenocorticotropic hormone).

About EffRx Pharmaceuticals

EffRx Pharmaceuticals is a commercial-stage pharmaceutical company focused on the late stage development and commercialization of prescription medications for niche and orphan indications. The business model is centered around providing superior clinical and commercial value propositions for physicians, payers and patients.

EffRx pro-actively seeks in-licensing opportunities for Europe in niche therapeutic areas, with a primary interest for rare diseases, where EffRx has received an orphan drug designation (ODD) from the FDA for a pipeline asset.

EffRx’s go-to-market competence is proven by the development, launch and lucrative expansion of Binosto® in a highly competitive European market.  Our lead commercialized product, Binosto® for the treatment of osteoporosis, is marketed in the US as well as selected European and Asian countries.

About Diurnal Group plc

Founded in 2004, Diurnal is a UK-headquartered, European specialty pharma company developing high quality products for the global market for the life-long treatment of chronic endocrine conditions, including congenital adrenal hyperplasia, adrenal insufficiency and hypogonadism. Its expertise and innovative research activities focus on circadian-based endocrinology to yield novel product candidates in the rare and chronic endocrine disease arena.

For further information about Diurnal, please visit www.diurnal.co.uk

Media contact: Ms. Pamela Saredi, psaredi@effrx.com

World Osteoporosis Day – WOD marked on October 20th: THAT’S OSTEOPOROSIS

Countdown to World Osteoporosis Day:
A digital countdown checklist is an easy way to learn good bone health basics.

Get Started Now!

WOD, marked on October 20 each year, is a year-long campaign dedicated to raising global awareness of the prevention, diagnosis and treatment of osteoporosis and related musculoskeletal diseases.

It aims to put bone health and fracture prevention on the global health agenda and reaches out to health-care professionals, the media, policy makers, patients, and the public at large.

Get tested and treated if required:
  • Could you be at risk of broken bones due to osteoporosis? Take the IOF Osteoporosis Risk Check to see whether any risk factors apply to you!
  • Have you broken a bone after age 50? Without treatment, one fracture leads to another.
  • Do you have a family history of broken bones? You could be at risk.
  • Are you getting shorter? This could be a sign of spine fractures due to osteoporosis.
  • Calcium is important for bone health. Are you getting enough of this important mineral? Find out with the IOF Calcium Calculator.
  • Osteoporosis affects 1 in 3 women and 1 in 5 men aged 50+ worldwide. Don’t let it affect you! Take action for prevention.

 

EffRx Mourns Passing of Board Member Anders Wiklund

FREIENBACH, Switzerland, 19th August 2020.

The leadership of EffRx Pharmaceuticals SA is extremely saddened to announce the passing of longtime Board Member and former Chairman, Anders P. Wiklund.

Anders, a Swedish citizen, has been a board member of EffRx since its incorporation in Switzerland in 2009, and served as Chairman of EffRx between 2015 and 2016. He also acted as CEO at former EffRx Inc., USA.

“Anders will be greatly missed by the entire EffRx family. We are deeply saddened by his passing and by the loss of a friend and colleague. We are especially honored for the entrepreneurial passion towards healthcare he carried in his heart and thankful for his outstanding leadership, experience and wisdom”, said Lorenzo Bosisio, CEO of EffRx. “Anders will always remain an indelible role model in our thoughts.”

On behalf of our Board of Directors, management team and employees, we extend our deepest sympathies to Anders’ family.

About EffRx Pharmaceuticals SA

EffRx Pharmaceuticals is a commercial-stage pharmaceutical company focused on the late-stage development and commercialization of prescription medications for niche and orphan indications. The business model is centered around providing superior clinical and commercial value propositions for physicians, payers and patients.

EffRx to Showcase Binosto® at the Virtual WCO-IOF-ESCEO 2020 Congress

EffRx Pharmaceuticals SA is proud to announce that it will participate in the 20th Edition of the World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, starting on the 20th of August 2020. The WCO-IOF-ESCEO Congress is the world’s leading clinical conference on bone, joint and muscle health and therefore the ideal venue for EffRx to showcase its flagship product Binosto®, the only buffered soluble alendronate for the treatment of postmenopausal osteoporosis.

EffRx Pharmaceuticals SA is also pleased to inform that a study on the cost-effectiveness of Binosto® will be presented at the WCO-IOF-ESCEO Congress. The data will be presented by Professor M. Hiligsmann in an oral communication (OC40) entitled, “COST-EFFECTIVENESS OF BINOSTO (BUFFERED SOLUBLE ALENDRONATE 70 MG) EFFERVESCENT TABLET FOR THE TREATMENT OF POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS IN ITALY.”

The authors of the cost-effectiveness study conclude that Binosto® represents a cost-effective strategy compared with generic alendronate, zoledronic acid and no treatment, and a dominant strategy compared to denosumab for the treatment of postmenopausal women with osteoporosis in Italy aged 60 years and over.

Medical professionals from around the world will be able to learn more about Binosto® and its exciting properties at the Binosto® virtual booth.

About EffRx Pharmaceuticals SA

EffRx Pharmaceuticals is a commercial-stage pharmaceutical company focused on the late-stage development and commercialization of prescription medications for niche and orphan indications. The business model is centered around providing superior clinical and commercial value propositions for physicians, payers and patients.

About Binosto®/Steovess®

Our lead commercialized product Binosto® is indicated for the treatment of osteoporosis and marketed in US, Europe and Asia. Binosto® (alendronate 70 mg effervescent tablets) is the first and only buffered solution for the treatment of postmenopausal osteoporosis. It reduces the risk of hip, spine, and non-spine fractures.1 The buffered solution with high acid-neutralizing capacity minimizes the risk of exposing the esophagus (in case of reflux) and the stomach to acidified alendronate.2,3 Binosto® is taken once a week as an easy-to-swallow, buffered solution with no risk of a tablet getting lodged in the esophagus. Binosto® has the potential to improve adherence to therapy4, thereby decreasing the risk of disabling fractures.

Disclaimer

Please refer to the official Binosto®/Steovess® prescribing information and approved indications, contraindications, and warnings in your country.

References:

  1. Black DM et al. Fracture Risk Reduction with Alendronate in Women with Osteoporosis: The Fracture Intervention Trial. J Clin Endocrinol Metab 2000;85:4118-4124.
  2. Binosto Summary of Product Characteristics. 2019.
  3. Hodges LA et al. Modulation of gastric pH by a buffered soluble effervescent formulation: A possible means of improving gastric tolerability of alendronate. Int J Pharm 2012;432:57-62.
  4. Giusti A et al. Persistence with Buffered Solution of Alendronate 70mg: Prospective Observational Study. J Bone Miner Res 2018;33(S1):S174-S175.